Laboratory for Clinical & Experimental Microbiology

Head of the laboratory:

Leonid P. TITOV
Professor, Doctor of Medical Sciences
Corresponding Member of the National Academy of Sciences,
foreign member of the Russian Academy of Medical Sciences

Tel.: + 375-172 37 69 98  
E-mail: This email address is being protected from spambots. You need JavaScript enabled to view it.

 

The staff of the Laboratory for Clinical & Experimental Microbiology

 

Main R&D & Collaboration Trends: 

 • phenotypic and genotypic characteristics study of pathogenic and commensal bacteria isolated from clinical material and environmental;
 
• study of gene polymorphism determining resistance in bacterial isolates, monitor trends in antimicrobial resistance among bacteria from humans and antibiotic consumption in medical institutions;

• study of morphological and functional properties of immune cells (B and T lymphocytes, dendritic cells) and molecules (cytokines) in infectious and immune diseases, the development immunomodulation and immunotherapy methods, polymorphism and gene expression of immune system cells by PCR and microarray;

• biotechnological development in creating culture media and test-systems;
 
• preparation of highly qualified scientific personnel, development of international scientific cooperation, assistance and practical health care.

Scientific and practical achievements

In the field of bacteriology

- Etiological structure, evolution, levels of antibiotic resistance of septic disease pathogens have been established, empirical chemotherapy forms have been developed (T.S. Ermakova, V.A. Gorbunov, E.F. Panshina, E.I. Gudkova E.G. Blyga, E.S. Nosova)

- The most important cause of infectious diarrhea studies are carried out (T. S. Ermakova, E.F. Panshina, E.I. Gudkov, L.D. Gaziumarova, O.O. Janovich, E.S. Nosova)

- For the first time in the country phenotypic and genetic studies in anaerobic bacteria are carried out - Clostridium difficile (N.V. Lebedkova) and Bacteroides (V.V. Slizen), the molecular epidemiology of diphtheria - Corynebacterium diphtheria (A.M. Dronina)

- The genetic mechanism of resistance MDR and XDR Mycobacterium tuberculosis are studied (Said Zucker Bostanabad, Mohammad Satter)

- Ultra-and nano-structured changes and mechanism of Pseudomonas aeruginosa resistance to disinfectants (I.A. Gavrilova)

- We study the phenotypic and genotypic properties of the causative agent of invasive bacterial diseases - Neisseria meningitidis (SE Glazkova, F. A. Lebedev, KV Sinyuk, O.O. Janovich, E.S. Nosova), Streptococcus pneumoniae (A.V. Davydov), Streptococcus pyogenes (V.V. Markevich), Haemophilus influenza type b (E.S. Nosova), Listeria monocytogenes (L.D. Gaziumarova, T.N. Bakaeva), Neisseria gonorrhoeae (F.A. Lebedev)

In the field of immunology

- Monitoring a children immune status living in the radionuclide contaminated territory, changes of lymphocytes, immunoglobulin class and subclass, DNA strand breaks and their correlation with the level of contamination of (I.E. Gurmanchuk, G.D. Haritonik, D.A. Chernoshey, E.Y. Kirilchik)

- Methods for immunodiagnosis and immunotherapy of patients with pregnancy pathology are developed (S. Dovban, Milko-Chernomorets)

- Research activity of the components of the classical and alternative pathways of complement activation in patients with sarcoidosis and in experiment (A.N. Batyan, V.V. Kochubinsky) and anti-C1q antibodies in autoimmune diseases (A.I. Kozyro, I.A. Peregud)

- Come up with new methods of immunity status assessment of patients with viral hepatitis B and C (V.A. Tarasyuk, L.S. Zhmurovskaya, A.E. Goncharov)

- Rapidly developing areas in the phenotypic characteristics of dendritic cells, the modulation of their functional properties, personalized vaccines for immunotherapy patients with breast cancer and patients with tuberculosis are created (A.E. Goncharov

- Immunotherapy  method with teotard combination for children with asthma are provides (T.G. Shilova)

- The close connection of virus-specific antibodies production with T cells and cytokines in individuals immunized with Grippol and Vaksigripp (A.M. Dashkevich)

- High efficacy of sublingual immunotherapy in patients with bronchial asthma are reviled (L.V. Maslova)

- Immunobiological properties of probiotics are studied (A.E. Goncharov, N.A. Pankanina, A.S. Murashko,  E.V. Besman)

- cytokine genes polymorphism in patients with infectious (mononucleosis, tuberculosis, Lyme borreliosis) and bronchial asthma are studied (O.O. Janovich, L.V. Maslova)

- Pilot research in the immune system gene expression by real-time PCR and microarray system are conducted (A.E. Goncharov, O.O. Janovich, M.V. Levchenya, K. Pavlov, E.V. Besman).