Laboratory for Immunology and Cell Biotechnology
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Head of the laboratory: Phone + 375-172 68 04 14 |
![]() Grigorieva E. Elena, PhD |
![]() Iryna V. RAMANAVA, Researcher |
![]() Siarhei V. KORAN, Researcher |
![]() Julianna A. KABANOVA, |
![]() Timohina V. Oksana, |
Rynda G. Alena, |
![]() Darya V. Babrukevich, |
![]() Veranika V. Zviarko, |
Liubov F. Fokina, |
|
Alena V. DUZH, Researcher |
Major areas of research:
- study of immune disorders in the patients with infectious, oncological and autoimmune diseases;
- dendritic cell-based treatment of cancer and autoimmune diseases;
- basophil activation test (BAT) in the diagnostics of pollen and drug allergy;
- study of human mesenchymal stem cells and its use in the treatment of autoimmune diseases and regenerative medicine;
- estimation of immunomodulatory drug efficacy using cell lines of lymphoid and myeloid origin as experimental models
- maintenance and replenishment of cryobank containing human and animal-derived cell lines (56 lines in May 2019);
- gene expression and delivery to a wide range of eukaryotic cells;
- development of technology for producing recombinant allergens and immunotherapy of allergic diseases.
Main Publications:
- Romanova, I.V. The Basophil activation test: technology of the method and application for clinical practice / Romanova I.V. Goncharov A.E. // Immunopathology, allergology, infectology 2018; 1:26-34.
- Regional anesthesia and the immune component stress response in oncosurgery / G.V. Ilukevich, L.R. Kaloshka, A.Y. Hancharou, I.V. Permyakov // Medical Journal – 2018. – № 2. – P. 7-12.
- Ramanava, I. U. Application of basophil activation and degranulation markers for diagnosis of pollen allergy / I. U. Ramanava, A. Y. Hancharou, N. I. Dudarava // Proceedings of the National Academy of Sciences of Belarus, Medical series – 2018. – Т. 15, № 4. – P. 405-413.
- Symanovich, V. U. Experimental models of atopic dermatitis / V. U. Symanovich , A. Y. Hancharou, L. A. Khvatova // Military medicine. – 2018. – № 2. – P. 113-117.
- Hancharou, A. Novel Basophil Activation and Degranulation Markers for the Basophil Activation Test / A. Hancharou, I. Ramanava, L. M. Dubuske // J. Allergy Clin. Immunol. – 2018. – Vol. 141, Issue 2, Suppl. – P. AB122. https://aaaai.confex.com/aaaai/wao18/webprogram/Paper34376.html.
- Human Olfactory Mucosa-Derived Mesenchymal Stem Cells Suppress Cytotoxic Functions of CD8+ T-Lymphocytes and Natural Killer Cells / A. Hancharou, N. Antonevich, O. Buschik, A. Rydna, V. Chekan, E. Strinkevich, L. M. Dubuske // J. Allergy Clin. Immunol. – 2018. – Vol. 141, Issue 2, Suppl. – P. AB228. https://aaaai.confex.com/aaaai/wao18/webprogram/Paper34369.html.
- Assessment of safety and tolerability of dendritic cell immunotherapy in patients with pancreatic cancer / A.Y. Hancharou, A.V. Prokhorov, O.V. Buschik, S.E. Romanoyskaya, L.M. Dubuske // Allergy. – 2018. – Vol. 73, Suppl. 105. – P.
- Association of memory T-cells subsets with osteoarthritis inflammatory activity / O.V. Degtereva, A.Y. Hancharou, E.V. Duzh, I.U. Ramanava, L.M. Dubuske // Allergy. –2018. – Vol. 73, Suppl. 105. – P. A15.
- Hancharou, A. Y. Effects of 3 different mushrooms, Ganoderma Lucidum, Lentinula Edodes and Boletus Edulis on T-cell and dendritic cell function / A.V. Duzh, A. Y. Hancharou, L. M. Dubuske // Allergy. –2018. – Vol. 73, Suppl. 104. – P.
- The clinical utility of basophil activation markers in the diagnosis of pollen allergy / Ramanava I. U., Hancharou A. Y., Osipova A. V., Dudareva N. I., Dubuske L. M. // Allergy. –2018. – Vol. 73, Suppl. 104– P.
- Antonevich, N. H. Modulation of cytotoxic activity of CD8+ lymphocytes and natural killer cells by human olfactory mucosa-derived mesenchymal stem cells / N. H. Antonevich, A. Y. Hancharou, L. M. Dubuske // European Academy of Allergy and Clinical Immunology Congress 2018, Munich, Germany, 26–30 May 2018 : abstr. [Publ. in] Allergy. – 2018 – Vol. 73, suppl. 104 – P. 276, # 479.
- Comparative Analysis Of The Co-Inhibitory Molecules Expression By The Mesenchymal Stem Cells Of Different Origin / A.Hancharou, N.Antonevich, A.Rynda, V. Kastsiunina, N. Petyovka, L.DuBuske // American College of Allergy, Asthma & Immunology (ACAAI) 2018 Annual Scientific Meeting, Seattle, USA, 15–19 November, 2018 : abstr. [Publ. in] Annals of Allergy, Asthma & Immunology. – 2018. – Vol. 121, № 5, suppl. – Р. S49.
- Mesenchymal Stem Cell Induce Tolerogenic Dendritic cells which Inhibit Proliferation of Autologous T-cells / A.Y. Hancharou, N.H. Antonevich, L. M. DuBuske // J. Allergy Clin. Immunol. - 2017. - Vol. 139, Issue 2, Suppl. - P. AB269.
- Immunophenotype and Subsets of Synoviocytes in Patients with Osteoarthritis / O.V. Degtereva, A. Y. Hancharou, I.U. Ramanava, A.V. Duzh, L. M. DuBuske // J. Allergy Clin. Immunol. - 2017. - Vol. 139, Issue 2, Suppl. - P. AB210.
- Assessment of changes in expression of immune system biomarkers to assist the differential diagnosis of acute bacterial infections / A. Hancharou, L. Du Buske // Allergy. 2017. Vol. 72. Suppl. 103. P. 191.
- Olfactory epithelium-derived mesenchymal stem cells impact antigen-presenting cells when co-cultured ex vivo / N. Antonevich, A. Hancharou, L. Du Buske // Allergy. 2017. Vol. 72. Suppl. 103. P. 477-478.
- The influence of the east asian mushrooms ganoderma lucidum and lentinula edodes and the belarussian mushroom boletus edulis on immune cell function / A. Duzh, A. Hancharou, L. Du Buske // Allergy. 2017. Vol. 72. Suppl. 103. P. 753.
- Decline in serum cytidine deaminaseactivity in patients with Hepatitis C infection / K. Pavlov, L. Titov, L. Du Buske // Allergy. 2017. Vol. 72. Suppl. 103. P. 495.
- Exhausted T-Cells and Memory T-Cell Subsets in Adult Varicella-Zoster Patients / L.M. DuBuske, A.Y. Hancharou, G.M. Davidovich // J. Allergy Clin. Immunol. 2016. Vol. 137, Issue 2, Supplement p1A, P.AB115
- Expression of CCR5 and CXCR4 on CD4+T-Lymphocytes in HIV-Positive Patients in Dependence on HIV-1 Subtype A Tropism / N. Matsiyeuskaya, I. Tokunova, D. Kireev, A. Hancharou // The 29th International Conference on Antiviral Re-search (ICAR): сб. науч. тр. Ла-Холья, США, 2016. С. 85.
- Comparative profile of surface and intracellular molecule expression in 10 immortalized human T cell lines to be considered for immunomodulatory drug evaluations / Hancharou A.Y., Duzh E.V., DuBuske L.M. // Allergy. 2016. Vol. 71. Suppl. 102. P.187.
- A Combined Method for Screening Novel Compounds for Immunomodulatory Activity / A. Duzh, A. Hancharou, L. DuBuske // Ann. Allergy Asthma Immunol. 2016. Vol. 117, N 5 (suppl.). P. S90–91.
- Serum cytidine deaminase activity in patients with viral infections / K. Pavlov, L. Titov, L. DuBuske // Ann. Allergy Asthma Immunol. 2016. Vol. 117, N 5 (suppl.). P. S117.