Laboratory for Immunology and Cell Biotechnology

Major areas of research:

  1. study of immune disorders in the patients with infectious, oncological and autoimmune diseases;
  2. dendritic cell-based treatment of cancer and autoimmune diseases;
  3. basophil activation test (BAT) in the diagnostics of pollen and drug allergy;
  4. study of human mesenchymal stem cells and its use in the treatment of autoimmune diseases and regenerative medicine;
  5. estimation of immunomodulatory drug efficacy using cell lines of lymphoid and myeloid origin as experimental models
  6. maintenance and replenishment of cryobank containing human and animal-derived cell lines (56 lines in May 2019); 
  7. gene expression and delivery to a wide range of eukaryotic cells;
  8. development of technology for producing recombinant allergens and immunotherapy of allergic diseases.
Head of the laboratory

Elena G. Fomina

Head of the laboratory


Phone.: + 375-172 68 04 14


Grigorieva E. Elena



Researcher, Candidate of medical Scienses

Siarhei V. KORAN


Julianna A. KABANOVA


Veranika V. Zviarko

Lab assistant of the 1st class

Main Publications
  1. Romanova, I.V. The Basophil activation test: technology of the method and application for clinical practice / Romanova I.V. Goncharov A.E. // Immunopathology, allergology, infectology 2018; 1:26-34.
  2. Regional anesthesia and the immune component stress response in oncosurgery / G.V. Ilukevich, L.R. Kaloshka, A.Y. Hancharou, I.V. Permyakov // Medical Journal – 2018. – № 2. – P. 7-12.
  3. Ramanava, I. U. Application of basophil activation and degranulation markers for diagnosis of pollen allergy / I. U. Ramanava, A. Y. Hancharou, N. I. Dudarava // Proceedings of the National Academy of Sciences of Belarus, Medical series – 2018. – Т. 15, № 4. – P. 405-413.
  4. Symanovich, V. U. Experimental models of atopic dermatitis / V. U. Symanovich , A. Y. Hancharou, L.  A. Khvatova // Military medicine. – 2018. – № 2. – P. 113-117.
  5. Hancharou, A. Novel Basophil Activation and Degranulation Markers for the Basophil Activation Test / A. Hancharou, I. Ramanava, L. M. Dubuske // J. Allergy Clin. Immunol. – 2018. – Vol. 141, Issue 2, Suppl. – P. AB122. https://aaaai.confex.com/aaaai/wao18/webprogram/Paper34376.html.
  6. Human Olfactory Mucosa-Derived Mesenchymal Stem Cells Suppress Cytotoxic Functions of CD8+ T-Lymphocytes and Natural Killer Cells / A. Hancharou, N. Antonevich, O. Buschik, A. Rydna, V. Chekan, E. Strinkevich, L. M. Dubuske // J. Allergy Clin. Immunol. – 2018. – Vol. 141, Issue 2, Suppl. – P. AB228. https://aaaai.confex.com/aaaai/wao18/webprogram/Paper34369.html.
  7. Assessment of safety and tolerability of dendritic cell immunotherapy in patients with pancreatic cancer / A.Y. Hancharou, A.V. Prokhorov, O.V. Buschik, S.E. Romanoyskaya, L.M. Dubuske // Allergy. – 2018. – Vol. 73, Suppl. 105. – P.
  8. Association of memory T-cells subsets with osteoarthritis inflammatory activity / O.V. Degtereva, A.Y. Hancharou, E.V. Duzh, I.U. Ramanava, L.M. Dubuske // Allergy. –2018. – Vol. 73, Suppl. 105. – P. A15.
  9. Hancharou, A. Y. Effects of 3 different mushrooms, Ganoderma Lucidum, Lentinula Edodes and Boletus Edulis on T-cell and dendritic cell function / A.V. Duzh, A. Y. Hancharou, L. M. Dubuske // Allergy. –2018. – Vol. 73, Suppl. 104. – P.
  10. The clinical utility of basophil activation markers in the diagnosis of pollen allergy / Ramanava I. U., Hancharou A. Y., Osipova A. V., Dudareva N. I., Dubuske L. M. // Allergy. –2018. – Vol. 73, Suppl. 104– P.
  11. Antonevich, N. H. Modulation of cytotoxic activity of CD8+ lymphocytes and natural killer cells by human olfactory mucosa-derived mesenchymal stem cells / N. H. Antonevich, A. Y. Hancharou, L. M. Dubuske // European Academy of Allergy and Clinical Immunology Congress 2018, Munich, Germany, 26–30 May 2018 : abstr. [Publ. in] Allergy. – 2018 – Vol. 73, suppl. 104 – P. 276, # 479.
  12. Comparative Analysis Of The Co-Inhibitory Molecules Expression By The Mesenchymal Stem Cells Of Different Origin / A.Hancharou, N.Antonevich, A.Rynda, V. Kastsiunina, N. Petyovka, L.DuBuske // American College of Allergy, Asthma & Immunology (ACAAI) 2018 Annual Scientific Meeting, Seattle, USA, 15–19 November, 2018 : abstr. [Publ. in] Annals of Allergy, Asthma & Immunology. – 2018. – Vol. 121, № 5, suppl. – Р. S49.
  13. Mesenchymal Stem Cell Induce Tolerogenic Dendritic cells which Inhibit Proliferation of Autologous T-cells / A.Y. Hancharou, N.H. Antonevich, L. M. DuBuske // J. Allergy Clin. Immunol. - 2017. - Vol. 139, Issue 2, Suppl. - P. AB269.
  14. Immunophenotype and Subsets of Synoviocytes in Patients with Osteoarthritis / O.V. Degtereva, A. Y. Hancharou, I.U. Ramanava, A.V. Duzh, L. M. DuBuske // J. Allergy Clin. Immunol. - 2017. - Vol. 139, Issue 2, Suppl. - P. AB210.
  15. Assessment of changes in expression of immune system biomarkers to assist the differential diagnosis of acute bacterial infections / A. Hancharou, L. Du Buske // Allergy. 2017. Vol. 72. Suppl. 103. P. 191.
  16.  Olfactory epithelium-derived mesenchymal stem cells impact antigen-presenting cells when co-cultured ex vivo / N. Antonevich, A. Hancharou, L. Du Buske // Allergy. 2017. Vol. 72. Suppl. 103. P. 477-478. 
  17. The influence of the east asian mushrooms ganoderma lucidum and lentinula edodes and the belarussian mushroom boletus edulis on immune cell function / A. Duzh, A. Hancharou, L. Du Buske // Allergy. 2017. Vol. 72. Suppl. 103. P. 753. 
  18. Decline in serum cytidine deaminaseactivity in patients with Hepatitis C infection / K. Pavlov, L. Titov, L. Du Buske // Allergy. 2017. Vol. 72. Suppl. 103. P. 495.
  19. Exhausted T-Cells and Memory T-Cell Subsets in Adult Varicella-Zoster Patients / L.M. DuBuske, A.Y. Hancharou, G.M. Davidovich // J. Allergy Clin. Immunol. 2016. Vol. 137, Issue 2, Supplement p1A, P.AB115
  20. Expression of CCR5 and CXCR4 on CD4+T-Lymphocytes in HIV-Positive Patients in Dependence on HIV-1 Subtype A Tropism / N. Matsiyeuskaya, I. Tokunova, D. Kireev, A. Hancharou // The 29th International Conference on Antiviral Re-search (ICAR): сб. науч. тр. Ла-Холья, США, 2016. С. 85.
  21. Comparative profile of surface and intracellular molecule expression in 10 immortalized human T cell lines to be considered for immunomodulatory drug evaluations / Hancharou A.Y., Duzh E.V., DuBuske L.M. // Allergy. 2016. Vol. 71. Suppl. 102. P.187.
  22. A Combined Method for Screening Novel Compounds for Immunomodulatory Activity / A. Duzh, A. Hancharou, L. DuBuske // Ann. Allergy Asthma Immunol. 2016. Vol. 117, N 5 (suppl.). P. S90–91.
  23. Serum cytidine deaminase activity in patients with viral infections / K. Pavlov, L. Titov, L. DuBuske // Ann. Allergy Asthma Immunol. 2016. Vol. 117, N 5 (suppl.). P. S117.